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Appendix cancer rates have quadrupled in millennials (born in the 1980s) compared to older generations, with a four percent annual increase – far outpacing most cancers. Most cases are undetected until advanced stages due to vague symptoms (abdominal pain, bloating, weight loss) and lack of screening protocols. Researchers suspect environmental or lifestyle factors (processed diets, microbiome disruption, toxins) and a "birth cohort effect," but the exact cause remains unknown. The surge mirrors rising early-onset gastrointestinal cancers (e.g., colorectal, pancreatic) in adults under 50, signaling a public health crisis. Doctors and patients must prioritize persistent symptoms; advocacy groups push for research into early detection and risk factors. Actor Adan Canto, best known for his roles in "X-Men" and "The Cleaning Lady," died at 42 from appendix cancer in January 2024. His tragic and early death exposed a disturbing medical trend: a sharp rise in appendiceal cancer among younger adults.